Columbia University, PhD (Behavioral Neuroscience)
Columbia University, MA (Behavioral Neuroscience)
University of Pennslyvania, BA (Psychology)
University of Pennsyvania, BS (Cognitive and Computer Science Engineering)
Psychological and Brain Sciences
The Nautiyal Lab is working on a number of projects towards the goal of understanding the neural basis of self-control. Our focus is on the serotonergic modulation of the the neural circuits underlying impulsive and aggressive behavior. We manipulate serotonin signaling using genetic and viral approaches in rodent models, and use a number of paradigms to assess behavior. The lab also uses microendoscopy for in vivo calcium imaging in freely-moving mice.
Assistant Professor of Clinical Neurobiology (in Psychiatry)
Mentor: Rene Hen
Psychiatry, Columbia University
Research funded by a K99, focused on delineating the neural circuits which contribute to impulsive behavior. First, by manipulating expression of the 5-HT1B receptor, Kate studied the mechanisms through which serotonin affects impulsivity. Next, using a factor analysis correlations between different measures of impulsivity were characterized, and covariates identified. Lastly, the K99 award supported her training in in vivo calcium imaging which can be used to image nodes in the neural circuits and identify cellular mechanisms for serotonergic effects on impulsivity.
Postdoctoral Research Fellow
Advisor: Rene Hen
Integrative Neuroscience, New York State Psychiatric Institute
2012 - 2015
Kate's postdoctoral work, funded by an individual postdoctoral NRSA (F32) dissociated the neural systems involved in impulsive and aggressive behavior. Specifically, her studies focused on the serotonin 1B receptor (5-HT1BR). Using a novel tissue-specific and inducible transgenic mouse, her work showed that distinct populations of 5-HT1BRs modulate the two behaviors, with aggressive behavior impacted by receptors in CaMKII+ cells during development and impulsive behavior mediated in adulthood by receptors on GABAergic neurons.
Graduate Research Fellow
Advisor: Rae Silver
Psychology Department, Columbia University
2005 - 2011
Kate's work in graduate school concerned the role of an immune cell, the mast cell, found in the brain. It's population in the brain varies under various behavioral and physiological states, but their functional role was unknown. Funded by a predoctoral NRSA (F31), her work showed that an absence of mast cells resulted in increased anxiety-like behavior in mice. Subsequent analysis showed that mast cells contribute serotonin to the hippocampus, and hippocampal-dependent behavior and neurogenesis were altered in mice that lack mast cells.
Advisor: Harvey Grill
Psychology Department, University of Pennsylvania
2003 - 2005
First as an undergraduate research assistant, and then as a research technician, Kate studied the neural basis of thermoregulatory control and feeding. Her research in the Grill Lab supported the idea that the caudal brainstem can regulate behavioral and physiological homeostatic responses independently of the hypothalamus. This included cold temperature and bacterial immune challanges. Except in the most extreme instances, the caudal brainstem was sufficient to coordinate normal responses.
Advisor: Aravind Joshi and Lila Gleitman
Institute for Research in Cognitive Science, University of Pennsylvania
2001 - 2003
During her time spent at the Institute for Research in Cognitive Science, Kate first worked on developing computational representations of complex sentneces with the XTAG research group. She also worked on a psycholinguistics project studying how the accentuation of pronounds determines their interpretation in discourse context. For her undergraduate senior capstone project for the dual degree program in Artificial Intelligence, Kate brought together research in the two fields of computational linguistics and psycholinguistics. By collecting adult predictions of muted videos of parents talking to their kids, we were able to begin developing a bootstrapping model for how children learn language.
Assistant Professor of Psychological and Brain Sciences
Neuroscience of Stress
Adjunct Assistant Professor, Lecturer
Department of Psychology, Columbia University
2011 - 2016
Mind, Brain and Behavior
Topics in Neurobiology and behavior
Department of Psychology, Columbia University
2005 - 2011
Li, Y., Simmler, L.D., Zessen, R.V., Flakowski, J., Wan, J.-X., Deng, F., Li, Y.-L., Nautiyal, K.M., Pascoli, V., and Lüscher, C.
(2021) Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science 373,
Desrochers, S.S., Lesko, E.M., Magalong, V.M., Balsam, P.D., Nautiyal, K.M. (2021) A role for reward valuation in the
serotonergic modulation of impulsivity. Psychopharmacology (Berl). Aug 14.
Lee,J.H., Capan, S., Lacefield, C., Shea,Y.M., Nautiyal, K.M (2020) DIY-NAMIC Behavior: A High-Throughput Method
Nautiyal, K.M., Okuda, M., Hen, R., Blanco, C. (2017) Gambling Disorder: An integrative review of animal
Zike, I.D., Chohan, M.O., Kopelman, J.M., Krasnow, E., Flicker, D., Nautiyal, K.M., Bubser, M.,
Kellendonk, C., Jones, C.K., Stanwood, G.D., Tanaka, K.F., Moore, H., Ahmari, S.E., Veenstra-
VanderWeele, J. (2017) OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity
Samuels, B.A.*, Nautiyal, K.M.*, Kruegel, A. C., Levinstein, M.R., Magalong, V.M., Gassaway, M.M.,
Grinnell, S.G., Han, J., Ansonoff, M.A., Pintar, J.E., Javitch, J.A., Sames, D., Hen, R. (2017) The
behavioral effects of the antidepressant tianeptine require the mu-opioid receptor.
Nautiyal, K.M., Hen, R. (2017) Serotonin receptors in depression: From A to B. F1000 Faculty Reviews
Nautiyal, K.M., Wang, S., Wall, M.W., Ahmari, S.E., Balsam, P.D., Blanco, C., Hen, R. (2017) Genetic and
modelling approaches reveal distinct components of impulsive behavior. Neuropsychopharmacology
Nautiyal, K.M., Tritschler, L., Ahmari, S.E. David, D.J., Gardier, A.M., Hen, R.(2016) A lack of serotonin 1B
autoreceptors results in a decrease in anxiety and depression-related behaviours. Neuropsychopharmacology
Nautiyal, K.M., Tanaka, K.F., Barr, M.M., Tritschler, L., LeDantec, Y., David, D.J., Gardier, A.M., Blanco,
C., Hen, R., Ahmari, S.E. (2015) Distinct circuits underlie the effects of 5-HT1B receptors on aggression
Knolhoff, A.M., Nautiyal, K.M., Nemes P., Kalachikov, S., Morozov, I., Silver, R., Sweedler, J.V.(2013)
Combining small-volume metabolomic and transcriptomic approaches for assessing brain chemistry.
Donaldson, Z.R., Nautiyal, K.M., Ahmari, S.E., Hen, R. (2013) Genetic approaches for understanding the
Nautiyal, K.M., Dailey, C., Jahn, J.L., Rodriguez, E., Sweedler, J.V., Silver, R. (2012) Serotonin of mast cell origin
Nautiyal, K.M. Immune cells in the brain. (2012) In: Neuroscience in the 21st Century, Ed. Donald Pfaff,
Springer Link. PDF
Nautiyal, K.M., Liu, C., Dong, X., Silver, R. (2011) Blood-borne donor mast cell precursors migrate to mast
Nautiyal, K.M., McKellar, H., Silverman, A.J., Silver, R. (2009) Mast cell involvement in the hypothermic response to
Nautiyal, K.M., Ribeiro, A., Pfaff, D.W., Silver, R. (2008) Brain mast cells link the immune system to anxiety-like
Nautiyal, K.M., Dailey, M., Brito, N., Brito, M.N., Harris, R.B, Bartness, T.J., Grill, H.J. (2008) Energetic responses to
cold temperatures in rats lacking forebrain-caudal brainstem connections. Am J Physiol 295(3): R789-98.